Symbol
Name
ID

Itga2
integrin alpha 2
MGI:96600

Phenotype annotations related to hematopoietic system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Increased circulating IgA level

Increased circulating IgE level

Epistaxis

Spontaneous, recurrent epistaxis

Excessive bleeding from superficial cuts

Gingival bleeding

Gastrointestinal hemorrhage

Intracranial hemorrhage

Subdural hemorrhage

Joint hemorrhage

Menorrhagia

Persistent bleeding after trauma

Prolonged bleeding after dental extraction

Prolonged bleeding after surgery

Prolonged bleeding following circumcision

Prolonged bleeding time

Bruising susceptibility

Purpura

Ecchymosis

Petechiae

Spontaneous hematomas

Abnormal megakaryocyte morphology

Increased megakaryocyte colony forming unit count

Anemia of inadequate production

Poikilocytosis

Acanthocytosis

Leukocytosis

Superficial thrombophlebitis

Reduced factor VIII activity

Impaired ristocetin-induced platelet aggregation

Reduced quantity of Von Willebrand factor

Prolonged whole-blood clotting time

Impaired platelet aggregation

Impaired ADP-induced platelet aggregation

Impaired arachidonic acid-induced platelet aggregation

Impaired collagen-induced platelet aggregation

Impaired collagen-related peptide-induced platelet aggregation

Impaired epinephrine-induced platelet aggregation

Impaired thrombin-induced platelet aggregation

Impaired thromboxane A2 agonist-induced platelet aggregation

Decreased platelet glycoprotein IIb-IIIa

Impaired clot retraction

Abnormal platelet count

Thrombocytopenia

Congenital thrombocytopenia

Intermittent thrombocytopenia

Abnormal platelet shape

Abnormal platelet volume

Decreased mean platelet volume

Disease(s) Associated with ITGA2

Behcet's disease

Glanzmann's thrombasthenia

thrombocytopenia

von Willebrand's disease 1

von Willebrand's disease 2

Mouse Phenotypes		hematopoietic system phenotype	decreased mean platelet volume	abnormal platelet physiology	abnormal platelet aggregation	decreased platelet aggregation
Availability	Mouse Genotype	hematopoietic system phenotype	decreased mean platelet volume	abnormal platelet physiology	abnormal platelet aggregation	decreased platelet aggregation
	Itga2^tm1.1Eck/Itga2^tm1.1Eck	*
	Itga2^tm1Ztr/Itga2^tm1Ztr
	Itga2^tm1.1Eck/Itga2⁺
	Itga2^tm1.1Tkun/Itga2^tm1.1Tkun Tg(Pf4-icre)Q3Rsko/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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